Overexpression of Lysyl Hydroxylase-2b Leads to Defective Collagen Fibrillogenesis and Matrix Mineralization
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منابع مشابه
petrology and geochemistry of khar-bash (western shahrood) and its relation ship to iron mineralization
منطقه مورد مطالعه در 23 کیلومتری جنوب غرب شهرستاشاهرود قرار دارد که در نقشه 100000/1 شاهرود قرار گرفته است.ناحیه مورد مطالعه در تقسیمات ساختاری ایران بخشی از زون البرز شرقی است . در طی سنوزوئیک این زون به شدت تحت تأثیر فازهای کوهزایی آلپی قرار گرفته و فعالیت های آتشفشانی انوسن در قسمت های غربی آن دیده می شود . از نظر ترکیب سنگ شناسی منطقه مورد مطالعه متنوع و بیشتر شامل سنگ های رسوبی مانند : آ...
15 صفحه اولImmunological characterization of lysyl hydroxylase, an enzyme of collagen synthesis.
Antibodies to pure lysyl hydroxylase from whole chick embryos were prepared in rabbits and used for immunological characterization of this enzyme of collagen biosynthesis. In double immunodiffusion a single precipitation line was seen between the antiserum and crude or pure chick-embryo lysyl hydroxylase. The antiserum effectively inhibited chick-embryo lysyl hydroxylase activity, whether measu...
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A patient is described with congenital hypotonia, lax joints, friable skin, hemorrhagic scars, high-arched palate, and borderline microcornea. Acid hydrolyzed whole skin collagen had a reduced hydroxylysine content of 0.5 residues per 1,000 as compared to 5.1 +/- 0.7 in control skin. Collagen lysyl hydroxylase in dialyzed subcellular fractions of cultured skin fibroblasts required L-ascorbate a...
متن کاملLysyl hydroxylase
1 1 4 7 jci.org Volume 125 Number 3 March 2015 Introduction Collagen is the most abundant intrinsic matrix scaffolding protein and contributes to tissue tensile strength (1). Various aspects of collagen metabolism, including its expression, deposition, organization, and turnover, are aberrant in epithelial cancer and have been implicated in tumor progression (2). Evidence from multiple types of...
متن کاملActivities of prolyl hydroxylase, lysyl hydroxylase, collagen galactosyltransferase and collagen glucosyltransferase in the liver of rats with hepatic injury.
The activities of four enzymes catalysing post-translational modifications of the collagen polypeptide chains were assayed in the livers of rats with experimental hepatic injury. The liver injury was induced by injecting carbon tetrachloride twice weekly, and assays of the enzymic activities were carried out 2 and 4 weeks after commencement of administration of carbon tetrachloride. The liver h...
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ژورنال
عنوان ژورنال: Journal of Bone and Mineral Research
سال: 2005
ISSN: 0884-0431
DOI: 10.1359/jbmr.2005.20.1.81